Altering Cortical Connectivity: Remediation-Induced Changes in the White Matter of Poor Readers
Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Summary
Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor readers. Prior to instruction, poor readers had significantly lower FA than good readers in a region of the left anterior centrum semiovale. The instruction resulted in a change in white matter (significantly increased FA), and in the very same region. The FA increase was correlated with a decrease in radial diffusivity (but not with a change in axial diffusivity), suggesting that myelination had increased. Furthermore, the FA increase was correlated with improvement in phonological decoding ability, clarifying the cognitive locus of the effect. The results demonstrate the capability of a behavioural intervention to bring about a positive change in cortico-cortical white matter tracts.
Figure 1. Fractional Anisotropy Increases following Remediation in Poor Readers in the Same Region of the Left Anterior Centrum Semiovale that Showed Reduced Fractional Anisotropy Relative to Good Readers Prior to the Instruction
(A) Region where the poor reader group showed an increase in FA between the preremediation and postremediation scans (peak t(34) = 5.12, at Montreal Neurological Institute [MNI] coordinates −12 28 36, spatial extent = 450 voxels, p <>
(B) Region showing a significant difference in FA between good readers and all poor readers at the first scan (peak t(70) = 4.66, at MNI coordinates −10 20 38, spatial extent = 418 voxels, p <>
http://www.cell.com/neuron/abstract/S0896-6273%2809%2900847-2
Copyright © 2009 Elsevier Inc.. All rights reserved.
Neuron, Volume 64, Issue 5, 624-631, 10 December 2009
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